Scientific Publications & Research
Explore the peer-reviewed scientific papers and clinical trials supporting TMDream.
TMDream's scientific foundations draw on peer-reviewed evidence in orofacial pain and related disorders. This bibliography includes foundational work by our Chief Scientist alongside the broader literature the platform builds on.
A novel artificial neural network for the diagnosis of orofacial pain and temporomandibular disorders
Volume 49, Issue 9, Pages 884-889. doi: 10.1111/joor.13350
Foundational paper validating a multilayer neural network for orofacial pain, migraines, headaches, bruxism, obstructive sleep apnea, and TMJ disorders, the clinical basis of TMDream.
Orofacial Pain and Toothache as the Sole Symptom of an Acute Myocardial Infarction Entails a Major Risk of Misdiagnosis and Death
Volume 34, Issue 1, Pages 53-60. doi: 10.11607/ofph.2480
Documents orofacial pain or toothache as the sole symptom of an acute myocardial infarction, with high risk of misdiagnosis and death if unrecognized.
Craniofacial pain can be the sole prodromal symptom of an acute myocardial infarction: an interdisciplinary study
Volume 29, Issue 1, Pages 23-28
Shows craniofacial pain can be the prodromal (early-warning) sign of a myocardial infarction, reinforcing the early-detection window for triage.
Craniofacial pain of cardiac origin is associated with inferior wall ischemia
Volume 28, Issue 4, Pages 317-321. doi: 10.11607/ofph.1257
Links cardiac facial pain to inferior-wall ischemia (vagal afferent pathway), giving physiological grounding to the referral pattern.
Quality Difference in Craniofacial Pain of Cardiac vs. Dental Origin
Volume 89, Issue 9, Pages 965-969. doi: 10.1177/0022034510370820
Establishes pain quality descriptors ('pressure' and 'burning' for cardiac origin; 'throbbing' and 'aching' for dental origin) for differential diagnosis.
Craniofacial pain as the sole symptom of cardiac ischemia: A prospective multicenter study
Volume 138, Issue 1, Pages 74-79. doi: 10.14219/jada.archive.2007.0027
Demonstrates that 38% of cardiac ischemia patients suffer from referred facial pain, serving as the sole symptom in 6% of cases.
Toothache of cardiac origin
Volume 13, Issue 3, Pages 201-207
The first paper in the series describing toothache as a manifestation of cardiac ischemia; the origin of this research line.
Bruxist Activity Monitor System (BAMS): An instrumental approach tool in the assessment of Bruxism
Volume 2021, Pages 1399-1402
Instrumentation research to measure bruxism objectively, complementary to TMDream's digital triage.
Tuberculosis of the temporomandibular joint: low prevalence or missed diagnosis?
Volume 24, Issue 4, Pages 234
Flags a rare TMJ pathology commonly overlooked, aligned with TMDream's focus on not missing infrequent diagnoses.
Occlusal stabilization appliances. Evidence of their efficacy
Volume 132, Issue 6, Pages 770-777. doi: 10.14219/jada.archive.2001.0274
Evidence review of occlusal splints for orofacial pain and bruxism management, one of the treatments TMDream accounts for.
Use of streptomycin-lidocaine injections in the treatment of the cluster-tic syndrome
Volume 24, Issue 5, Pages 289-292
Contributes clinical experience in complex neuralgias and headaches, one of the orofacial pain domains the system covers.
Academic Collaborations
Our research group led by Dr. Marcelo Kreiner collaborates directly with Umeå University (Sweden), University of Kentucky (USA), and UdelaR (Uruguay), integrating cardiologists, sleep doctors, dentists, and AI engineers for maximum clinical accuracy.